Reinier Boon
Professor
Research interests
Ageing of the cardiovascular system.
The main focus of the research in the lab is ageing of the cardiovascular system. This is the main risk factor for cardiovascular disease and we are interested in the role of so-called non-coding RNA in this process. Current focus lies on long non-coding RNAs (lncRNAs), which control key cellular processes in endothelial cells and cardiomyocytes. We study lncRNAs in these cells that are (dys)regulated during ageing and aim to identify targets for therapeutic intervention. Our studies include functional in vitro and in vivo models, as well as molecular biology and biochemical assays.
Recent publications (see OrcID / Pure)
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- Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020 11(1):2039.
- Juni RP, Phelp PG, Bink DI, Kremer V, van Bergen AS, Espin Gonzalez P, Rombouts KB, Harber KJ, Heister DAF, Yeung KK, Van den Bossche J, Kuster DWD; Amsterdam UMC COVID-19 Biobank Study Group Krijnen PAJ, Niessen HWM, Boon RA. COVID19 Impairs Cardiac Function via Endothelial H19 and IL6 Signaling. Circ Res. 2023 132(5):648-651.
- Boon RA,* Iekushi K,* Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. MicroRNA-34a controls cardiac aging and function. Nature 2013 495(7439):107-10
Ongoing research projects
- ERC Consolidator (NICCA)
- Horizon 2020 consortium (CardioReGenix)
- DZHK-BHF-DHF International Cardiovascular Research Partnership (ReGenLnc)
- DFG CRC (TRR267)
Group members
- Rio Juni – Post doc
- Anke van Bergen – Lab manager
- Susanne Koziarek – Lab manager
- Ruggero Belluomo – PhD student
- Lily Jalink – PhD student
- Amber Schonk – PhD student
- Noelia Bellon Quinones – PhD student