email: e.eringa@amsterdamumc.nl

Research interests

My research line focuses on microvascular dysfunction in cardiometabolic diseases, ultimately resulting in vital organ failure. Specifically, I aim to elucidate the role of fat tissue around arteries, or perivascular adipose tissue (PVAT), in metabolic and contractile muscle function. This research started with a hypothesis paper published in The Lancet and has resulted in evidence that PVAT controls muscle blood flow through a balance of vasodilator and vasoconstrictor products, known as adipokines. While the balance between these two is tilted towards vasodilator adipokines in normal physiology, it shifts towards vasoconstrictor adipokines in human and experimental obesity, preceding symptoms of diseases such as type 2 diabetes.

After starting my research on microvascular dysfunction in muscle, I have translated this mechanistic knowledge to cardiac diseases associated with type 2 diabetes and impaired microvascular function. In these studies I study mechanisms that reduce tissue blood flow in non-obstructive coronary artery disease and heart failure with preserved ejection fraction. In this research I collaborate with cardiologists and endocrinologists.

Key publications

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1. Vink CEM, de Jong EAM, Woudstra J, Molenaar M, Kamp O, Götte MJW, van Raalte DH, Serné E, van de Hoef TP, Chamuleau SAJ, Eringa EC, Appelman Y. The role of myocardial blood volume in the pathophysiology of angina with non-obstructed coronary arteries: The MICORDIS study. International Journal of Cardiology 2024: 132479.
2. Kane J, Vos WG, Bosmans LA, van Os BW, den Toom M, Hoeksema‐Hackmann S, Moen‐de Wit D, Gijbels MJ, Beckers L, Grefhorst A, Levels JHM, Jakulj L, Vervloet MG, Lutgens E, Eringa EC. Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE-/- Mice. Journal of the American Heart Association 2024; 13: e034066.
3. Canto ED, van Deursen L, Hoek AG, Elders PJM, den Ruijter HM, van der Velden J, van Empel V, Serné EH, Beulens JWJ, Eringa EC. Microvascular endothelial dysfunction in skin is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes: the Hoorn Diabetes Care System Cohort. Cardiovascular Diabetology 2023; 22: 234.
4. Turaihi AH, Serné EH, Molthoff CFM, Koning JJ, Knol J, Niessen HW, Goumans M, van Poelgeest EM, Yudkin JS, Smulders YM, Jimenez CR, van Hinsbergh VWM, Eringa EC. Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles. Diabetes 2020; 69: 603-613.
5. Padro T, Manfrini O, Bugiardini R, Canty J, Cenko E, De Luca G, Duncker DJ, Eringa EC, Koller A, Tousoulis D, Trifunovic D, Vavlukis M, de Wit C, Badimon L. ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on ‘coronary microvascular dysfunction in cardiovascular disease’. Cardiovascular Research 2020; 116: 741-755.

Ongoing research

• CVON RECONNEXT, Dutch Heart Foundation
• It takes three to tango, ZonMW

Group Members

Amsterdam UMC

• Jamie Kane, PhD student
• Maarten Graumans, PhD student
• Soufiane Nassiri, PhD student
• Marta Hanczar, PhD student

Maastricht University

• Elisa d’Alessandro, postdoc
• Geertje Swennen, technician
• Sanne Mourmans, PhD student
• Christos Konstantaros, PhD student
• Pip van Lier, PhD student

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