Bianca BrundelProfessor

RESEARCH INTERESTS

Role of protein homeostasis and the protein quality control system underlying atrial fibrillation

Bianca Brundel received her PhD from the University Medical Center Groningen, The Netherlands and was trained in molecular and cellular biology (VU, Amsterdam) and clinical pharmacology (UMCG). Bianca is professor at the physiology department at the VU University Medical Center Amsterdam. Her research is focused on the molecular mechanisms driving proteostasis derailment and pathophysiology of cardiac diseases, including atrial fibrillation and cardiomyopathies. Molecular findings are used to identify novel druggable targets. Her laboratory utilizes experimental cardiomyocyte and Drosophila cardiac disease models in combination with genetic and pharmacological manipulations. She is project leader of translational research projects and founder of the Atrial Fibrillation Innovation Platform (www.AFIPonline.org) to promote translational studies in collaboration with patients. As such, she contributed to forwarding candidate drugs into (pre-)clinical proof-of-principle studies.

 

RECENT PUBLICATIONS

Henning RH, Brundel BJJM: Proteostasis in cardiac health and disease. Nature Reviews Cardiology, 2017. PMID 28660894

Nolte I, Munoz ML, .. Brundel BJJM, De Geus E, Snieder H. VgHRV GWAS. Nature Communication 2017. PMID 28613276

Zhang D, Hu X, Henning RH, Brundel BJJM. Role of HDACs in cardiac proteostasis in atrial fibrillation. Cardiovasc Res. 2016;109:519-26. PMID 26645980

Zhang D, Wu CT, Qi X, Meijering RAM, Hoogstra-Berends F, Tadevosyan A, Cubukcuoglu Deniz G, Durdu S, Akar AR, Sibon OCM, Nattel S, Henning RH, Brundel BJJM. Activation of HDAC6 induces contractile dysfunction in experimental and human Atrial Fibrillation. Circulation 2014; 129:346-58. PMID 24146251

Den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM et al. Heart rate-associated loci and their effects on conduction. Nature Genetics 2013; 45:621-31. PMID 23583979

 

ONGOING RESEARCH PROJECTS

2017-2021: CVON grant AFFIP: Atrial Fibrillation FIngerPrinting: Spotting bio-electrical markers to early recognize atrial fibrillation by the use of a bottom-up approach (AFFIP) Project leaders: Dr. Natasja de Groot (EMC) and Prof. Dr. B. Brundel (VUmc)

2015-2020: CVON grant DOSIS: Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches. Project leaders: Prof. J. van der Velden and Prof. R. de Boer (UMCG), PI Prof. Dr. B. Brundel (VUmc), www.cvon-dosis.nl

2014-2019: Established investigator, Dutch Heart Foundation: REVersal of cardiomyocyte structural remodeling and Improvement of functional recoVEry in Atrial Fibrillation. REVIVE

2014-2018: LSH grant. HSF1 activators lower cardiomyocyte damage: towards a novel therapeutic approach to reverse Atrial Fibrillation. HALT&REVERSE (Consortium leader)
With: Dr. N. de Groot (EMC), Nyken BV, Dutch Heart Foundation

2014-2018: Dutch Heart Foundation funded grant: Juvenile Cardiomyopathy. Boosting chaperone networks to counteract juvenile DCM caused by chaperone mutations. (co-PI)
With: Prof. H. Kampinga (UMCG) and Prof. J. van der Velden (VUmc)

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