2018

Publications 2018. Please click on the document icon for publication link.

Peters EL, Comerford D, Vaz FM, van der Laarse WJ
Meijer and Vloedman’s histochemical demonstration of mitochondrial coupling obeys Lambert-Beer’s law in the myocardium.
Histochemistry and cell biology. 29th August 2018

Parbhudayal RY, Garra A, Götte MJW, Michels M, Pei J, Harakalova M, Asselbergs FW, van Rossum AC, van der Velden J, Kuster DWD
Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology. 28th August 2018

Dorsch LM, Schuldt M, Knežević D, Wiersma M, Kuster DWD, van der Velden J, Brundel BJJM
Untying the knot: protein quality control in inherited cardiomyopathies.
Pflugers Archiv: European journal of physiology. 14th August 2018

Dias-Neto M, Meekel JP, van Schaik TG, Hoozemans J, Sousa-Nunes F, Henriques-Coelho T, Lely RJ, Wisselink W, Blankensteijn JD, Yeung KK
High Density of Periaortic Adipose Tissue in Abdominal Aortic Aneurysm.
European journal of vascular and endovascular surgery. 13th August 2018

Groeneveld ME, Meekel JP, Rubinstein SM, Merkestein LR, Tangelder GJ, Wisselink W, Truijers M, Yeung KK
Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture.
Journal of the American Heart Association. 30th June 2018

Ter Horst EN, Hahn NE, Geerts D, Musters RJP, Paulus WJ, van Rossum AC, Meischl C, Piek JJ, Niessen HWM, Krijnen PAJ
p47phox-Dependent Reactive Oxygen Species Stimulate Nuclear Translocation of the FoxO1 Transcription Factor During Metabolic Inhibition in Cardiomyoblasts.
Cell Biochemistry and Biophysics. 29th June 2018

Dekker NAM, van Meurs M, van Leeuwen ALI, Hofland HM, van Slyke P, Vonk ABA, Boer C, van den Brom CE
Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats.
British Journal of Anaesth. 19th June 2018

Meijering RAM, Wiersma M, Zhang D, Lanters EAH, Hoogstra-Berends F, Scholma J, Diks S, Qi X, de Groot NMS, Nattel S, Henning RH, Brundel BJJM
The application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling.
Heart Rhythm. 11th June 2018

Nijenkamp LLAM, Bollen IAE, van Velzen HG, Regan JA, van Slegtenhorst M, Niessen HWM, Schinkel AFL, Krüger M, Poggesi C, Ho CY, Kuster DWD, Michels M, van der Velden J
Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy.
Circulation. Heartfailure. 11th June 2018

Wiersma M, Beuren TMA, de Vrij EL, Reitsema VA, Bruintjes JJ, Bouma HR, Brundel BJJM, Henning RH
Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system.
Comp Biochem Physiol B Biochem Mol Biol. 9th June 2018

Alma LJ, De Groot CJM, De Menezes RX, Hermes W, Hordijk PL, Kovačević I
Endothelial dysfunction as a long-term effect of late onset hypertensive
pregnancy disorders: High BMI is key.
European Journal of Obstetrics & Gynecology and Reproductive Biology. Jun 2018

Koning NJ, de Lange F, van Meurs M, Jongman RM, Ahmed Y, Schwarte LA, van Nieuw Amerongen GP, Vonk ABA, Niessen HW, Baufreton C, Boer C
Reduction of vascular leakage by imatinib is associated with preserved microcirculatory perfusion and reduced renal injury markers in a rat model of cardiopulmonary bypass.
British Journal of Anaestheasia. Jun 2018

Meekel JP, Groeneveld ME, Bogunovic N, Keekstra N, Musters RJP,
Zandieh-Doulabi B, Pals G, Micha D, Niessen HWM, Wiersema AM, Kievit JK, Hoksbergen AWJ, Wisselink W, Blankensteijn JD, Yeung KK
An in vitro method to keep human aortic tissue sections functionally and structurally intact.
Scientific Reports. May 25th 2018

Chandrupatla DMSH, Molthoff CFM, Ritsema WIGR, Vos R, Elshof E, Matsuyama T, Low PS, Musters RJP, Hammond A, Windhorst AD, Lammertsma AA, van der Laken CJ, Brands R, Jansen G
Prophylactic and therapeutic activity of alkaline phosphatase
in arthritic rats: single-agent effects of alkaline phosphatase and synergistic
effects in combination with methotrexate.

Translational Research. May 17th 2018

Baniaamam M, Paulus WJ, Blanken AB, Nurmohamed MT
The effect of biological DMARDs on the risk of congestive heart failure in rheumatoid arthritis: a systematic review.
Expert opinion on biological therapy. March 26th 2018

Lindqvist J, van den Berg M, van der Pijl R, Hooijman PE, Beishuizen A, Elshof J, de Waard M, Girbes A, Spoelstra-de Man A, Shi ZH, van den Brom C, Bogaards S,  Shen S, Strom J, Granzier H, Kole J, Musters RJP, Paul MA, Heunks LMA, Ottenheijm CAC
Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in
Diaphragm Fibers.
American Journal of Respiratory and Critical Care Medicine. March 26th 2018

Esse R, Teerlink T, Koolwijk P, Tavares de Almeida I, Blom HJ, Castro R
Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells.
Nutrients. March 24th 2018

Tramper J, Vonk Noordegraaf A, Meijboom LJ, Zwitserloot AM, Straver B, Aman J
A Rare Hemodynamic Cause of Airway Obstruction.
American Journal of Respiratory and Critical Care Medicine. March 5th 2018

Wijnker P, Sequeira V, Kuster D, Velden JV
Hypertrophic cardiomyopathy: a vicious cycle triggered by sarcomere mutations and secondary disease hits.
Antioxidants & Redox Signaling. February 28th 2018

Kovačević I, Sakaue T, Majoleé J, Pronk MC, Maekawa M, Geerts D,
Fernandez-Borja M, Higashiyama S, Hordijk PL
The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.
Journal of Cell Biology. January 22nd 2018

Szulcek R, Bollensdorff C, Hordijk P, Gabriel M
The covalently immobilized antimicrobial peptide LL37 acts as a VEGF mimic and stimulates endothelial cell proliferation.
Biochem Biophys Res Commun. January 20th 2018

Wüst RCI, Stienen GJM
Successive contractile periods activate mitochondria at the onset of contractions in intact rat cardiac trabeculae.

Journal of Applied Physiology. January 11th 2018

2017

Publications 2017. Please click on the document icon for publication link.

Heunks L, Ottenheijm C
Diaphragm Protective Mechanical Ventilation to Improve Outcome in ICU Patients?
American Journal of Critical Care Medicine. November 28th 2017

da Silva Gonçalves Bos D, Van Der Bruggen CE, Kurakula K, Sun XQ, Casali KR, Casali AG, Rol N, Szulcek R, Dos Remedios C, Guignabert C, Tu L, Dorfmuller P, Humbert M, Wijnker PJM, Kuster DWD, van der Velden J, Goumans MJ, Bogaard HJ, Vonk-Noordegraaf A, de Man FS, Handoko ML
Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Circulation. November 22nd 2017

Amado-Azevedo J, Reinhard NR, van Bezu J, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL
The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity.
Vascular Pharmacology. November 21st 2017

Groeneveld ME, Bogunovic N, Musters RJP, Tangelder GJ, Pals G, Wisselink W, Micha D, Yeung KK
Betaglycan (TGFBR3) up-regulation correlates with increased TGF-β signaling in Marfan patient fibroblasts in vitro.
Cardiovascular Pathology. November 4th 2017

Wiersma M, Meijering RAM, Qi XY, Zhang D, Liu T, Hoogstra-Berends F, Sibon OCM, Henning RH, Nattel S, Brundel BJJM
Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human  Atrial Fibrillation.
Journal of the American Heart Association. October 24th 2017

Bollen IAE, van der Velden J
The contribution of mutations in MYH7 to the onset of cardiomyopathy.
Netherlands Heart Journal. October 20th 2017

van der Velden J
Targeting High Oxygen Consumption to Prevent Cardiac Dysfunction in Patients With Aortic Valve Stenosis.
Circulation Cardiovascular Imaging. October 10th 2017

Reinhard NR, Mastop M, Yin T, Wu Y, Bosma EK, Gadella TWJ Jr, Goedhart J, Hordijk PL
The balance between Gα(i)-Cdc42/Rac and Gα(12)/(13)-RhoA pathways determines endothelial barrier regulation by Sphingosine-1-Phosphate.
Molecular Biology of the Cell. September 27th 2017

Pronk MCA, van Bezu JSM, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL
RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Small GTPases. September 26th 2017

Bollen IAE, Ehler E, Fleischanderl K, Bouwman F, Kempers L, Ricke-Hoch M, Hilfiker-Kleiner D, Dos Remedios CG, Krüger M, Vink A, Asselbergs FW, van Spaendonck-Zwarts KY, Pinto YM, Kuster DWD, van der Velden J
Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared to dilated cardiomyopathy and ischemic heart disease.
American Journal of Pathology. September 18th 2017

Peters EL, van der Linde SM, Vogel ISP, Haroon M, Offringa C, de Wit GMJ, Koolwijk P, van der Laarse WJ, Jaspers RT
IGF-1 Attenuates Hypoxia-Induced Atrophy but Inhibits Myoglobin Expression in C2C12 Skeletal Muscle Myotubes.
International Journal of Molecular Sciences. September 1st 2017

Amado-Azevedo J, Reinhard NR, van Bezu J, de Menezes RX, van Beusechem VW, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL
A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.
Scientific Reports. August 31st 2017

van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CA
Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.
American Journal of Respiratory and Critical Care Medicine. August 8th 2017

Groeneveld ME, van der Reijden JJ, Tangelder GJ, Westin LC, Renwarin L, Musters RJP, Wisselink W, Yeung KK
Peroxynitrite Footprint in Circulating Neutrophils of Abdominal Aortic Aneurysm Patients Is Lower in Statin than in Non-statin Users.
European Journal of Vascular & Endovascular Surgery. July 14th 2017

Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T
Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.
Angiogenesis. July 11th 2017

Henning RH, Brundel BJJM
Proteostasis in cardiac health and disease.
Nature Reviews Cardiology, June 29th 2017

McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG
MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
PLoS One. June 28th 2017

van Deel ED, Najafi A, Fontoura D, Valent E, Goebel M, Kardux K, Falcão-Pires  I, van der Velden J
In vitro model to study the effects of matrix stiffening on  Ca(2+) handling and myofilament function in isolated adult rat cardiomyocytes.
Journal of Physiology. June 21st 2017

Sequeira V, van der Velden J
The Frank-Starling Law: a jigsaw of titin proportions.
Biophysical Reviews. June 21st 2017

Waddingham MT, Paulus WJ
Microvascular Paradigm in Heart Failure With Preserved Ejection Fraction: A Quest for Proof of Concept.
Circulation Heart Failure. June 13th 2017

Bollen IAE, Schuldt M, Harakalova M, Vink A, Asselbergs FW, Pinto JR, Krüger M, Kuster DWD, van der Velden J
Genotype-specific pathogenic effects in human dilated cardiomyopathy. J Physiol.
Journal of Physiology. June 1st 2017

Bollen IAE, van der Velden J
Distinguish mutation specific pathogenic effects from secondary disease remodeling: An essential but often overlooked concept.
Cardiovascular Research, May 25th 2017

van der Laarse WJ
Heart heat separation.
Journal of Physiology. May 25th 2017

Güçlü A, Knaapen P, Harms HJ, Parbhudayal RY, Michels M, Lammertsma AA, van Rossum AC, Germans T, van der Velden J
Disease Stage-Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy.
Circulation: Cardiovascular Imaging. May 10th 2017

Hu X, Van Marion DMS, Wiersma M, Zhang D, Brundel BJJM
The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation.
Cell Stress Chaperones. May 8th 2017

Schaefer A, van Duijn TJ, Majolee J, Burridge K, Hordijk PL
Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro.
Journal of Immunology. May 8th 2017

Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S
Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
Cardiovascular research. May 1st 2017

de Winter JM, Ottenheijm CAC

Sarcomere Dysfunction in Nemaline Myopathy.
J Neuromusculular Diseases. April 19th 2017

Attaye I, Smulders YM, de Waard MC, Oudemans-van Straaten HM, Smit B, Van Wijhe MH, Musters RJ, Koolwijk P, Spoelstra-de Man AME
The effects of hyperoxia  on microvascular endothelial cell proliferation and production of vaso-active substances.
Intensive Care Medicine Expimental. April 13th 2017

Turaihi AH, van Poelgeest EM, van Hinsbergh VW, Serné EH, Smulders YM, Eringa EC
Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion.
Journal of Visualized Experiments. March 20th 2017

Wüst RC, Helmes M, Martin JL, van der Wardt TJ, Musters RJ, van der Velden J,  Stienen GJ
Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.
Journal of Physiology. March 15th 2017

Franssen C, Kole J, Musters R, Hamdani N, Paulus WJ
α-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes.
Circulation Heart Failure. March 10th 2017

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP
Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.
Circulation.  March  28th 2017

Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S, Squire I
Circular RNAs in heart failure.
European Journal of Heartfailure. March 27th 2017

Manavski Y, Abel T, Hu J, Kleinlützum D, Buchholz CJ, Belz C, Augustin HG, Boon RA, Dimmeler S
Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.
PNAS.  March 27th 2017

Smeets MW, Bierings R, Meems H, Mul FP, Geerts D, Vlaar AP, Voorberg J, Hordijk PL
Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor.
PLoS One. March 1st 2017

Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner C, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S
Shear stress-regulated miR-27b controls pericyte recruitment by repressing
SEMA6A and SEMA6D.
Cardiovascular research. February 23rd 2017

Boa BC, Yudkin JS, van Hinsbergh VW, Bouskela E, Eringa EC
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular  function.
British Journal of Pharmacology. February 1st 2017

Alma LJ, Bokslag A, Maas AHEM, Franx A, Paulus WJ, de Groot CJM
Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis.
ESC Heart Failure. January 30th 2017

Yeung KK, Bogunovic N, Keekstra N, Beunders AA, Pals J, van der Kuij K, Overwater E, Wisselink W, Blankensteijn JD, van Hinsbergh VW, Musters RJ, Pals G, Micha D, Zandieh-Doulabi B
Transdifferentiation of Human Dermal Fibroblasts to Smooth Muscle-Like Cells to Study the Effect of MYH11 and ACTA2 Mutations in Aortic Aneurysms.
Human Mutation. January 27th 2017

Guazzi M, van Heerebeek L, Paulus WJ
Phosphodiesterase-5 inhibition in heart  failure with preserved ejection fraction: trading therapy for prevention.
European Journal of Heartfailure. January 19th 2017

Paulus WJ, Waddingham MT
Racial Tension in Hypertension: Divergent Effects of African and European Ancestry on Cardiac Remodeling.
JACC Heart Failure. January 11th 2017

van Hinsbergh VW
Osteoglycin’s embracement of VEGF receptor-2 limits angiogenesis and collateralization.
Cardiovascular Research. January 9th 2017

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